Ib pab neeg tshawb fawb sib koom ua ke los ntawm Tsev Kawm Ntawv Kho Mob Harvard (HMS) thiab MIT General Tsev Kho Mob hais tias lawv tau ua tiav qhov kev tso tawm ntawm microdisk laser siv PEC etching txoj kev, ua qhov chaw tshiab rau nanophotonics thiab biomedicine "kev cog lus."
(Cov zis ntawm microdisk laser tuaj yeem hloov kho los ntawm PEC etching txoj kev)
Hauv cov teb ntawmnanophotonicsthiab biomedicine, microdisklasersthiab nanodisk lasers tau dhau los ua kev cia siabqhov chaw teebthiab soj ntsuam. Hauv ntau daim ntawv thov xws li on-chip photonic kev sib txuas lus, on-chip bioimaging, biochemical sensing, thiab quantum photon cov ntaub ntawv ua, lawv yuav tsum ua kom tiav laser tso zis nyob rau hauv kev txiav txim wavelength thiab ultra-nqa band raug. Txawm li cas los xij, nws tseem nyuaj rau tsim microdisk thiab nanodisk lasers ntawm no meej wavelength ntawm qhov loj. Cov txheej txheem nanofabrication tam sim no qhia qhov randomness ntawm disc txoj kab uas hla, uas ua rau nws nyuaj rau kom tau ib lub teeb wavelength nyob rau hauv laser loj ua thiab ntau lawm.Tam sim no, ib pab neeg ntawm cov kws tshawb fawb los ntawm Harvard Medical School thiab Massachusetts General Tsev Kho Mob Wellman Center rauOptoelectronic Tshuajtau tsim ib qho tshiab optochemical (PEC) etching cov txheej txheem uas pab kom meej lub laser wavelength ntawm ib tug microdisk laser nrog subnanometer raug. Cov haujlwm no tau luam tawm hauv phau ntawv xov xwm Advanced Photonics.
Photochemical etching
Raws li cov lus ceeb toom, pab neeg no txoj kev tshiab ua rau kev tsim cov micro-disk lasers thiab nanodisk laser arrays nrog meej, predetermined emission wavelengths. Tus yuam sij rau qhov kev puas tsuaj no yog kev siv PEC etching, uas muab txoj hauv kev ua tau zoo thiab muaj peev xwm los kho qhov wavelength ntawm microdisc laser. Hauv cov txiaj ntsig saum toj no, pab pawg ua tiav tau txais indium Gallium arsenide phosphating microdisks npog nrog silica ntawm indium phosphide kem qauv. Tom qab ntawd lawv tau kho lub laser wavelength ntawm cov microdisks precisely rau tus nqi txiav txim los ntawm kev ua photochemical etching nyob rau hauv ib tug diluted tov ntawm sulfuric acid.
Lawv kuj tau tshawb xyuas cov txheej txheem thiab kev hloov pauv ntawm cov txheej txheem tshwj xeeb photochemical (PEC) etchings. Thaum kawg, lawv tau hloov lub wavelength-tuned microdisk array mus rau polydimethylsiloxane substrate los tsim kev ywj pheej, cais cov khoom laser nrog cov laser wavelengths sib txawv. Qhov tshwm sim microdisk qhia tau hais tias ib qho ultra-wideband bandwidth ntawm laser emission, nrog raulasernyob rau hauv kem tsawg dua 0.6 nm thiab cais particle tsawg dua 1.5 nm.
Qhib qhov rooj rau kev siv biomedical
Qhov txiaj ntsig no qhib qhov rooj rau ntau yam tshiab nanophotonics thiab biomedical applications. Piv txwv li, stand-alone microdisk lasers tuaj yeem ua physico-optical barcodes rau heterogeneous biological kuaj, ua kom cov ntawv sau ntawm cov xov tooj tshwj xeeb thiab cov hom phiaj ntawm cov molecules tshwj xeeb hauv multiplex tsom xam.Cell hom-specific labeling yog tam sim no ua siv cov pa biomarkers, xws li Raws li cov organic fluorophores, quantum dots, thiab fluorescent hlaws, uas muaj qhov dav dav emission linewidths. Yog li, tsuas yog ob peb lub xov tooj tshwj xeeb tuaj yeem sau npe tib lub sijhawm. Nyob rau hauv sib piv, lub ultra-nqaim band teeb emission ntawm ib tug microdisk laser yuav muaj peev xwm txheeb xyuas ntau hom cell nyob rau tib lub sij hawm.
Pab neeg no tau sim thiab ua tiav tau ua tiav qhov tseeb kho microdisk laser hais raws li biomarkers, siv lawv los sau cov kab mob ntawm lub mis epithelial MCF10A. Nrog lawv cov emission ultra-wideband, cov lasers tuaj yeem hloov pauv biosensing, siv cov pov thawj biomedical thiab kho qhov muag xws li cytodynamic imaging, flow cytometry, thiab multi-omics tsom xam. Cov thev naus laus zis raws li PEC etching cim qhov ua ntej loj hauv microdisk lasers. Lub scalability ntawm txoj kev, raws li zoo raws li nws subnanometer precision, opens li tshiab muaj peev xwm rau suav tsis tau daim ntawv thov ntawm lasers nyob rau hauv nanophotonics thiab biomedical li, raws li zoo raws li barcodes rau tej cell pejxeem thiab analytical molecules.
Post lub sij hawm: Jan-29-2024